Decidualization resistance in the origin of preeclampsia.
Por:
Garrido-Gomez T, Castillo-Marco N, Cordero T, Simon C
Publicada:
1 feb 2022
Ahead of Print:
29 sep 2020
Resumen:
Preeclampsia is a major obstetrical complication with short- and long-term life-threatening consequences for both mother and child. Shallow cytotrophoblast invasion through the uterine decidua into the spiral arteries is implicated in the pathogenesis of preeclampsia, although the cause of deficient arterial invasion remains unknown. Research that is focused on the "soil"-the maternal decidua-highlights the importance of this poorly understood but influential uterine layer. Decidualization of endometrial cells regulates embryo invasion, which is essential for spiral artery remodeling and establishing the maternal-fetal interface. Exploration of the association between impaired decidualization and preeclampsia revealed suboptimal endometrial maturation and uterine natural killer cells present in the decidua before preeclampsia development. Furthermore, decidualization defects in the endometrium of women with severe preeclampsia, characterized by impaired cytotrophoblast invasion, were detected at the time of delivery and persisted 5 years after the affected pregnancy. Recently, a maternal deficiency of annexin A2 expression was found to influence aberrant decidualization and shallow cytotrophoblast invasion, suggesting that decidualization resistance, which is a defective endometrial cell differentiation during the menstrual cycle, could underlie shallow trophoblast invasion and the poor establishment of the maternal-fetal interface. Based on these findings, the transcriptional signature in the endometrium that promotes decidualization deficiency could be detected before (or after) conception. This would serve to identify women at risk of developing severe preeclampsia and aid the development of therapies focused on improving decidualization, perhaps also preventing severe preeclampsia. Here, we discuss decidualization deficiency as a contributor to the pathogenesis of pregnancy disorders with particular attention to severe preeclampsia. We also review current diagnostic strategies and discuss future directions in diagnostic methods based on decidualization.
Filiaciones:
Garrido-Gomez T:
Igenomix Foundation-Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain
Castillo-Marco N:
Igenomix Foundation-Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain
Cordero T:
Igenomix Foundation-Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain
Simon C:
Igenomix Foundation-Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain. Department of Obstetrics and Gynecology, School of Medicine, University of Valencia, Spain. Department of Obstetrics and Gynecology, BIDC, Harvard University, Boston, USA
Open Access
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