Idiopathic Pulmonary Fibrosis and Telomeres.
Por:
Mulet A, Signes-Costa J
Publicada:
22 nov 2022
Ahead of Print:
22 nov 2022
Resumen:
Idiopathic pulmonary fibrosis is an interstitial lung disease of unknown etiology with a highly compromised prognosis and a significant mortality rate within a few years of diagnosis. Despite being idiopathic, it has been shown that telomeric shortening could play an important role in its etiopathogenesis. Mutations in telomere-related genes have been identified, but they are not always present despite telomere shortening. On the other hand, this telomeric shortening has been linked to a worse prognosis of the disease independently of other clinical factors, implying it may serve as a biomarker.
Filiaciones:
Mulet A:
Hosp Clin, Dept Pulmonol, Valencia 46010, Spain
INCLIVA, Resp Dis Res Grp, Valencia 46010, Spain
Signes-Costa J:
Hosp Clin, Dept Pulmonol, Valencia 46010, Spain
INCLIVA, Resp Dis Res Grp, Valencia 46010, Spain
gold, Green Published
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