The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study
Por:
Sideli L, Aas M, Quattrone D, La Barbera D, La Cascia C, Ferraro L, Alameda L, Velthorst E, Trotta G, Tripoli G, Schimmenti A, Fontana A, Gayer-Anderson C, Stilo S, Seminerio F, Sartorio C, Marrazzo G, Lasalvia A, Tosato S, Tarricone I, Berardi D, D'Andrea G, Arango C, Arrojo M, Bernardo M, Bobes J, Sanjuan J, Santos J, Menezes P, Del-Ben C, Jongsma H, Jones P, Kirkbride J, Llorca P, Tortelli A, Pignon B, de Haan L, Selten J, Van Os J, Rutten B, Bentall R, Di Forti M, Murray R, Morgan C, Fisher H
Publicada:
1 oct 2023
Ahead of Print:
1 jun 2023
Resumen:
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
Filiaciones:
Sanjuan J:
Department of Psychiatry, School of Medicine, Universidad de Valencia, Centro de Investigación Biomédica en Red de Salud Mental, Valencia, Spain
Department of Human Science, LUMSA University, Piazza delle Vaschette, 101, 00193, Rome, Italy.
Green Published, Green Submitted, Green Accepted, hybrid
FULL TEXT
 |
Published Version |
|
| No Accesible |
|