Optimal dose and pattern of physical activity to prevent diagnosed depression: prospective cohort study
Por:
Andersen L, López-Bueno R, Kandola A, Núñez-Cortés R, López-Bueno L, Calatayud J
Publicada:
4 feb 2025
Ahead of Print:
4 feb 2025
Resumen:
Background Little is known about the dose and pattern of moderate-to-vigorous physical activity (MVPA) to prevent depression. We aimed to assess the prospective association of dose and pattern of accelerometer-derived MVPA with the risk of diagnosed depression.Methods We included 74,715 adults aged 40-69 years from the UK Biobank cohort who were free of severe disease at baseline and participated in accelerometer measurements (mean age 55.2 years [SD 7.8]; 58% women). MVPA at baseline was derived through 1-week wrist-worn accelerometry. Diagnosed depression was defined by hospitalization with ICD-10 codes F32.0-F32.A. Restricted cubic splines and Cox regression determined the prospective association of dose and pattern of MVPA with the risk of incident depression.Results Over a median 7.9-year follow-up, there were 3,089 (4.1%) incident cases of depression. Higher doses of MVPA were curvilinearly associated with lower depression risk, with the largest minute-per-minute added benefits occurring between 5 (HR 0.99 [95% CI 0.96-0.99]) and 280 (HR 0.67 [95% CI 0.60-0.74]) minutes per week (reference: 0 MVPA minutes).Conclusion Regardless of pattern, higher doses of MVPA were associated with lower depression risk in a curvilinear manner, with the greatest incremental benefit per minute occurring during the first 4-5 h per week. Optimal benefits occurred around 15 h/week.
Filiaciones:
Andersen L:
Natl Res Ctr Working Environm, Copenhagen, Denmark
Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark
López-Bueno R:
Natl Res Ctr Working Environm, Copenhagen, Denmark
Univ Zaragoza, Dept Phys Med & Nursing, Zaragoza, Spain
Univ Valencia, Dept Physiotherapy, Exercise Intervent Hlth Res Grp EXINH RG, Valencia, Spain
Kandola A:
UCL, MRC Unit Lifelong Hlth & Ageing, London, England
UCL, Inst Mental Hlth, London, England
Núñez-Cortés R:
Univ Chile, Fac Med, Dept Phys Therapy, Santiago, Chile
López-Bueno L:
Univ Valencia, Dept Physiotherapy, Exercise Intervent Hlth Res Grp EXINH RG, Valencia, Spain
Calatayud J:
Natl Res Ctr Working Environm, Copenhagen, Denmark
Univ Valencia, Dept Physiotherapy, Exercise Intervent Hlth Res Grp EXINH RG, Valencia, Spain
Green Submitted, Green Published, hybrid
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