Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis.
Por:
Gonzalez-Ortega I, Gonzalez-Pinto A, Alberich S, Echeburua E, Bernardo M, Cabrera B, Amoretti S, Lobo A, Arango C, Corripio I, Vieta E, de la Serna E, Rodriguez-Jimenez R, Segarra R, Lopez-Ilundain J, Sanchez-Torres A, Cuesta M, Zorrilla I, Lopez P, Bioque M, Mezquida G, Barcones F, De-la-Camara C, Parellada M, Espliego A, Alonso-Solis A, Grasa E, Varo C, Montejo L, Castro-Fornieles J, Baeza I, Dompablo M, Torio I, Zabala A, Eguiluz J, Moreno-Izco L, Sanjuan J, Guirado R, Caceres I, Garnier P, Contreras F, Bobes J, Al-Halabi S, Usall J, Butjosa A, Sarro S, Landin-Romero R, Ibanez A, Selva G, PEPs Group:
Publicada:
1 ene 2020
Ahead of Print:
22 oct 2019
Resumen:
Background. Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the direction of their associations is not clear. Therefore, the main aim of this study was to analyze the influence of social cognition as a mediator between cognitive reserve and cognitive domains on functioning in FEP both at baseline and at 2 years.
Methods. The sample of the study was composed of 282 FEP patients followed up for 2 years. To analyze whether social cognition mediates the influence of cognitive reserve and cognitive domains on functioning, a path analysis was performed. The statistical significance of any mediation effects was evaluated by bootstrap analysis.
Results. At baseline, as neither cognitive reserve nor the cognitive domains studied were related to functioning, the conditions for mediation were not satisfied. Nevertheless, at 2 years of follow-up, social cognition acted as a mediator between cognitive reserve and functioning. Likewise, social cognition was a mediator between verbal memory and functional outcome. The results of the bootstrap analysis confirmed these significant mediations (95% bootstrapped CI (-10.215 to -0.337) and (-4.731 to -0.605) respectively).
Conclusions. Cognitive reserve and neurocognition are related to functioning, and social cognition mediates in this relationship.
Filiaciones:
Gonzalez-Ortega I:
PEPs Group
Gonzalez-Pinto A:
PEPs Group
Alberich S:
PEPs Group
Echeburua E:
PEPs Group
Bernardo M:
PEPs Group
Cabrera B:
PEPs Group
Amoretti S:
PEPs Group
Lobo A:
PEPs Group
Arango C:
PEPs Group
Corripio I:
PEPs Group
Vieta E:
PEPs Group
de la Serna E:
PEPs Group
Rodriguez-Jimenez R:
PEPs Group
Segarra R:
PEPs Group
Lopez-Ilundain J:
PEPs Group
Sanchez-Torres A:
PEPs Group
Cuesta M:
PEPs Group
Zorrilla I:
PEPs Group
Lopez P:
PEPs Group
Bioque M:
PEPs Group
Mezquida G:
PEPs Group
Barcones F:
PEPs Group
De-la-Camara C:
PEPs Group
Parellada M:
PEPs Group
Espliego A:
PEPs Group
Alonso-Solis A:
PEPs Group
Grasa E:
PEPs Group
Varo C:
PEPs Group
Montejo L:
PEPs Group
Castro-Fornieles J:
PEPs Group
Baeza I:
PEPs Group
Dompablo M:
PEPs Group
Torio I:
PEPs Group
Zabala A:
PEPs Group
Eguiluz J:
PEPs Group
Moreno-Izco L:
PEPs Group
Sanjuan J:
INCLIVA, University of Valencia, Hospital Clinico Universitario of Valencia, Spain
Guirado R:
Neurobiology Unit, Department of Cell Biology, Interdisciplinary Research Structure for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Valencia, Spain
Caceres I:
PEPs Group
Garnier P:
PEPs Group
Contreras F:
PEPs Group
Bobes J:
PEPs Group
Al-Halabi S:
PEPs Group
Usall J:
PEPs Group
Butjosa A:
PEPs Group
Sarro S:
PEPs Group
Landin-Romero R:
PEPs Group
Ibanez A:
PEPs Group
Selva G:
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, INCLIVA Health Research Institute, Valencia, Spain
PEPs Group::
PEPs Group
Green Published, Green Submitted, hybrid
FULL TEXT
 |
Published Version |
|
| No Accesible |
|